Abstract for presentation at 11th International Congress of Human Genetics

The role of Fatty acid binding protein-4 (FABP4) gene expression in human epicardial adipose tissue and aorta of metabolic syndrome patients with previous myocardial infarction

  • Dr Burcak Vural, Istanbul University, Institute for Experimental Medical Research, Department of Genetics, Istanbul, Turkey
  • Dr Fatmahan Atalar, Istanbul University, Institute for Experimental Medical Research, Department of Genetics, Istanbul, Turkey
  • Dr Cavlan Ciftci, Kadirhas University, Medical Faculty, Department of Cardiology, Istanbul, Turkey
  • Ayse Demirkan, Istanbul University, Institute for Experimental Medical Research, Department of Genetics, Istanbul, Turkey
  • Dr Belgin Susleyici Duman, Kadirhas University, Medical Faculty, Department of Medical Biology and Genetics, Istanbul, Turkey
  • Dr Belhhan Akpinar, IFlorence Nightingale Hospital, Department of Cardiac Surgery, Istanbul, Turkey
  • Dr Ugur Ozbek, Istanbul University, Institute for Experimental Medical Research, Department of Genetics, Istanbul, Turkey
  • Dr A Buyukdevrim, Turkish Diabetes Consortium, Istanbul

    • Adipocyte fatty acid binding protein (FABP4) is member of intracellular FABP family and expressed in a differentiation-dependent fashion in adipocytes. In mice, targeted mutations in FABP4 provide significant protection from hyperinsulinemia and insulin resistance in the context of both dietary and genetic obesity.
    In this study, we compared FABP4 gene expression in 10 metabolic syndrome and control tissue samples (n=5) without metabolic syndrome, in paired epicardial adipose tissue and aorta biopsies. Gene expressions were determined by real time RT-PCR. Positive correlations were found between body mass index (BMI) and FABP4 gene expression (0.6941, p<0.05), (0.6732, p<0.05) and between previous myocardial infarction (PMI) and FABP4 gene expression (0.5854, p<0.05),(0.6693, p<0.05) in both paired epicardial adipose tissue and aorta, respectively. The positive correlation between BMI and FABP4 gene expression, in both paired epicardial adipose tissue and aorta led us to think that FABP4 is responsible for obesity in metabolic syndrome. Whereas, we did not find any correlation between FABP4 gene expression and glycemia, lipid profile and hypertension. There was no correlation between FABP4 gene expression and coronary artery disease (CAD) or acute myocardial infarction (AMI). The decrease in FABP4 expression might be due to the statin used by all patients. A positive correlation between PMI and FABP4 expression might indicate an association with necrosis in the patients.

    Conference Organiser - ICMS Pty Ltd