Abstract for presentation at 11th International Congress of Human Genetics

Influence of Serotonin Transporter and Receptor Gene Polymorphisms on Cognitive Abilities in a Community-based Australian Sample

  • Holly Mack, The Centre for Mental Health Research, Australia
  • Mr Simon Easteal, Predictive Medicine Group, Australian National University, Australia
  • Prof Helen Christensen, Australia
  • Dr Kaarin Anstey, Australia
  • Mr Anthony Jorm, ORYGEN Research Group, University of Melbourne, Australia

    • Previous studies have shown serotonin is involved in learning and memory, but it is not fully understood the role of serotonin in normal cognitive function. The present study investigates the relationship between serotonin-1A (5-HT1A) receptor and serotonin transporter polymorphism (5-HTTLPR) and cognitive performance over time.
    The analyzed sample comprised of subjects from an ongoing Australian epidemiology study entitled "The PATH Through Life" project (PATH), randomly selected from electoral rolls in the ACT. Initial data collection began in 1999, with follow-up data collected four years later, resulting in a total sample size of 7,485 adults in three age groups (20-24, 40-44, 60-64). A short test battery was utilized to measure cognitive function, which consisted of an immediate memory test (Californian Verbal Learning Test), working memory (digit span), a measure of psychomotor speed (Symbol Digit Modalities Test), a word knowledge test (Spot-the-Word), and simple tests of reaction. In addition, the 60+ cohort was administered a dementia screening questionnaire (Mini-Mental State Examination). Associations between the 5-HT1A receptor and 5-HTTLPR genotypes and cognitive ability at both time points will be presented.

    Conference Organiser - ICMS Pty Ltd