Abstract for presentation at 11th International Congress of Human Genetics

Glutathione-S-transferase M1 polymorphisms and susceptibility to esophageal cancer among three Chinese minorities: the Kazakh, Uygur and Tajik

  • Dr Xiao-Mei Lu, Medical Research Center, 1st Teaching Hospital, Xinjiang Medical University, Urumqi 830054, Xingjian Uygur Autonomous Region, C, China
  • Prof Hao Wen, Medical Research Center, 1st Teaching Hospital, Xinjiang Medical University, Urumqi 830054, Xingjian Uygur Autonomous Region, C, China
  • Ms Ting Yang, Medical Research Center, 1st Teaching Hospital, Xinjiang Medical University, Urumqi 830054, Xingjian Uygur Autonomous Region, C, China
  • Dr Mangsu Song, School of Public Health and Family Medicine, Capital University of Medical Sciences, Beijing, China, China
  • Wei Wang, China

    • Only a small proportion of individuals resident in high-risk areas for esophageal cancer (EC) develop the disease, although they share the same environment and have very similar lifestyles, suggesting that the host genetic background may play an important role in EC development. This study investigated glutathione-S-transferase M1 (GSTM1) polymorphisms in three Chinese minorities, the Kazakh, Uygur, and Tajik, and investigated the pathological significance of GSTM1 polymorphisms in esophageal carcinogenesis among Kazakhs. Blood samples were obtained from healthy individuals (442 males and 679 females) in Xinjiang, China (654 Kazakhs, 412 Uygurs and 55 Tajiks). Esophageal squamous cell cancer (ESCC) tissue was also obtained from 116 Kazakh patients who underwent surgery in the No.1 Teaching Hospital of Xinjiang Medical University and the People’s Hospital of Xinjiang Uygur Autonomous Region, China. GSTM1 polymorphisms were analyzed by a combined approach of PCR and electrophoresis. The GSTM1 null genotype was found in 62.6% of Uygurs, 50.9% of Tajiks and 30.4% of Kazakhs. The GSTM1 null genotype was significantly higher in Uygurs compared to Kazakhs (OR:2.475, 95%CI:1.921-3.189, chi-squared=50.09, p=0.000). In addition, the Kazakh ethnic population exhibited GSTM1 null genotype distributions of 23.5% in well-differentiated and 49.2% in poorly differentiated ESCC (OR:3.152, 95%CI:1.403-7.080, chi-squared=8.018, p=0.007). In summary, there was a marked difference in the frequency of the common GSTM1 null genotype between the Uygur and Kazakh populations, and the GSTM1 null genotype was positively associated with differentiation of ESCC among Kazakhs.

    Conference Organiser - ICMS Pty Ltd