Abstract for presentation at 11th International Congress of Human Genetics

Insertion/Deletion (I/D) polymorphism in Angiotensin Converting Enzyme (ACE) in mexican women with breast cancer

  • Dr Maria Moran Moguel, Centro de Investigación Biomédica de Occidente. Instituto Mexicano del Seguro Social, Mexico
  • Biol Xochitl Castro, Centro de Investigación Biomédica de Occidente. Instituto Mexicano del Seguro Social, Mexico
  • Dr Susan Gutierrez, Centro de Investigación Biomédica de Occidente. Instituto Mexicano del Seguro Social, Mexico
  • Dr Adriana Mendizabal, Centro de Investigación Biomédica de Occidente. Instituto Mexicano del Seguro Social, Mexico
  • Dr Jose Vazquez, Centro Médico Nacional de Occidente. Instituto Mexicano del Seguro Social, Mexico
  • Dr Jose Sanchez, Centro de Investigación Biomédica de Occidente. Instituto Mexicano del Seguro Social, Mexico

    • The renin angiotensin system plays an important role in homeostasis and its main effector, angiotensin II, has been shown to have possible mitogenic and angiogenic effects in human cell lines and animal models of breast cancer. A recent study observed lower breast cancer incidence in female users of ACE inhibitors relative to nonusers with comparable cardiovascular conditions. I/D polymorphism is a marker of circulating ACE levels and the I allele has been recently inversely related with breast cancer risk. The Mexican population is in Hardy-Weinberg equilibrium with respect this polymorphism. Objetive. The aim of the present study was to investigate the frequencie and evaluate the relationship of the I/D polymorphism with breast cancer risk in Mexican postmenopausal women. Methods. The ACE I/D polymorphism was genotyped by PCR with specific primers in 94 paraffin-embedded tissue biopsy (56 breast cancer cases and 38 tissue samples with benign breast disease). Results. The genotype frequencies in cases were II: 0.12, ID: 0.09 and DD: 0.78 and in controls were II: 0.03 ID: 0.1 and DD: 0.87.The DD carriers showed a significantly increased risk of developing breast cancer when compared with the I/D and I/I carriers (Odds ratio, 3.46; 95% confidence interval, 1.659-7.228; P = 0.00063). Conclusions. Our results suggest that the ACE I/D polymorphism plays an important role in breast cancer and benign breast disease risk in Mexican women.

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