Abstract for presentation at 11th International Congress of Human Genetics

A sample of 152 sib-pair families from Indonesia for analysis of linkage and association in schizophrenia

  • Prof Dieter Wildenauer, University of Western Australia, Australia
  • Dr Irmansyah, University of Indonesia, Indonesia
  • Dr Herlina Handoko, Queensland Centre for Schizophrenia Research, Australia
  • Prof Assen Jablensky, University of Western Australia, Australia
  • Prof Wolfgang Maier, University of Bonn, Germany
  • Dr Sibylle Schwab, University of Western Australia, Australia

    • Schizophrenia is a devastating mental disorder affecting approximately 1% of the population worldwide. A genetic contribution to the development of the disorder has been well established by numerous family, twin, and adoption studies, suggesting a polygenic, multi-factorial background of the disorder with a number of susceptibility genes rather than single, disease causing genes. Despite a similar incidence across populations, differences in outcome and course, i. e. a milder course in developing countries, suggest the possibility that different genes or different gene combinations contribute to the illness. We have ascertained a sample of 152 families with at least two affected offspring from Indonesia. The sample comprises 93 families with both parents available for diagnosis and genotyping, and 59 families with one parent, but additional unaffected siblings for reconstruction of the missing parental genotype. There were 138 pairs and 14 triplets, comprising altogether 686 individuals with 318 of them affected with schizophrenic disorders as diagnosed by the DSM and ICD criteria. Genomic DNA had been isolated from all samples and used for analysis of association with DNA-variants in candidate genes. A genome-wide linkage scan with 400 microsatellite markers is being performed at the Marshfield Clinic Research Foundation, NHLBI Mammalian Genotyping Service.

    Conference Organiser - ICMS Pty Ltd