Abstract for presentation at 11th International Congress of Human Genetics

Evolutionary History of the Human X Chromosome

  • Dr Matthew Wakefield, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
  • Dr Edda Koina, ARC Centre for Kangaroo Genomics, Research School of Biological Sciences, The Australian National University, Canberra, ACT0200, Australia
  • Mr Tim Hore, ARC Centre for Kangaroo Genomics, Research School of Biological Sciences, The Australian National University, Canberra, ACT0200, Australia
  • Dr Janine Deakin, ARC Centre for Kangaroo Genomics, Research School of Biological Sciences, The Australian National University, Canberra, ACT0200, Australia
  • Dr Amber Alsop, ARC Centre for Kangaroo Genomics, Research School of Biological Sciences, The Australian National University, Canberra, ACT0200, Australia
  • Dr Anthony Papenfuss, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
  • Prof Jennifer Graves, ARC Centre for Kangaroo Genomics, Research School of Biological Sciences, The Australian National University, Canberra, ACT0200, Australia

    • The Human X chromosome contains regions with differing evolutionary history. We have integrated recent information from whole genome sequencing of marsupials and monotremes with cytogenetic mapping and chromosome painting to reconstruct the evolution of the X chromosome from the ancestral mammal.
    Reciprocal best hits of ensembl predicted transcripts were used to compare the genomic location and organization of genes from fully sequenced genomes. This data was integrated with gene mapping data and chromosome painting data from tammar wallaby (Macropus eugenii) and unsequenced taxa. The genomic organization of regions that are on the human X chromosomes were reconstructed to infer the organization in the common ancestor of all mammals and the eutherian and marsupial ancestors.
    We discuss the implications of the evolutionary history of the mammalian X chromosome for the development of X chromosome inactivation.

    Conference Organiser - ICMS Pty Ltd