Abstract for presentation at 11th International Congress of Human Genetics

Cytogenetics Epidemiology of Down Syndrome in Iran A forty years study

  • Dr M Shariaty, Cytogenetics Lab. , Dep. of Med. Gent. Sch. Med. Bushehr Uni., Iran
  • Dr I Nabipour MD2, Persian Gulf Heal Res. Cent, Bushehr Uni.
  • Dr F Zangeneh MD3, Dept. Endoc. Mayo Clinic, USA
  • Dr A Madani, Dept. Child Nephro, Children’s Hospt, Tehran Uni.
  • Dr R Pazoki MD2, Persian Gulf Heal Res. Cent, Bushehr Uni.
  • Dr S Azimi PhD 5, Cytogenetics Lab. (Founded 1965 by Dr.M.Shariaty ), Dept. Med. Gent. Can. Res. Inst, Tehran
  • Miss M Rassaei BS1, Cytogenetics Lab. , Dep. of Med. Gent. Sch. Med. Bushehr Uni.
  • Miss F Farzanfar BS5, Cytogenetics Lab. (Founded 1965 by Dr.M.Shariaty ), Dept. Med. Gent. Can. Res. Inst, Tehran

    • Objective: To determine the Cytogenetics Profile of Down Syndrome (DS) patients and its epidemiologic pattern in Iranian population.
    Methods: We are reporting a retrospective analysis of 827 patients, referred to cytogenetics laboratories of Tehran and Bushehr Medical Sciences Universities in the period between November 1965 and December 2004. Detailed background information of all patients was registered at the time of initial evaluation. The patient’s peripheral blood samples were cultured using the standard technique of Morhead and were karyotyped accordingly. Since 1972, the samples were karyotyped at the 300-400 resolution G- banding level. Data were analyzed using descriptive statistics using SPSS-11 Software.
    Results: Abnormal DS related karyotypes were observed in 579 patients, 326 males and 253 females. About 60 percent of DS patients were born in Tehran Metropolitan area. Frequency of free trisomy 21, translocation 21, and mosaicism, were 89.5%, 5.3% and 5.2% respectively. Parents of 10.4% of patients with DS were products of consanguineous marriages but in 89.6% there was no family relationships. The Mean ages of parents of DS patients were 28.49 (7.71 SD) for fathers and 34.67 (9.14 SD) years for mothers. Half of our DS cases were the results of first (159 cases) or second (120 cases) pregnancies.
    Conclusion: Our study is showing a different picture regarding parental age and parity in Down syndrome patients compared to other reported studies world wide. These findings warrant further investigations to determine the etiologic causes of these unique characteristics in our region.

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