Abstract for presentation at 11th International Congress of Human Genetics

Recent Advancements of H-Invitational Database, An Integrated Database of the Human Transcriptome

  • Tadashi Imanishi, BIRC, AIST, Japan
  • Ms Chisato Yamasaki, JBIRC, JBIC, Japan
  • Mr Katsuhiko Murakami, JBIRC, JBIC, Japan
  • Dr Yasuyuki Fujii, JBIRC, JBIC, Japan
  • Dr Motohiko Tanino, JBIRC, JBIC, Japan
  • Dr Yumi Yamaguchi-Kabata, BIRC, AIST, Japan
  • Dr Takashi Gojobori, CIB-DDBJ, NIG, Japan

    • We present recent advancements of H-Invitational Database (H-InvDB; http://www.h-invitational.jp/), an integrated database of human transcriptome based on extensive annotation of human full-length cDNA (FLcDNA) clones. The latest release of H-InvDB (release 3.0, in preparation) includes all human mRNAs in the DNA databank in addition to FLcDNAs, in order to expand its coverage to the whole human transcriptome. The database consists of descriptions of their gene structures, alternative splicing isoforms, functional non-protein-coding RNAs, functional domains of proteins, predicted subcellular localizations, metabolic pathways, predictions of protein 3D structure, mapping of SNPs and microsatellite repeat motifs, co-localization with orphan diseases, gene expression profiles, and comparisons with genes of major mammalian species in the context of molecular evolution. We conducted several kinds of extensive sequence analyses for quality control to provide a reliable human transcriptome database. All the data in H-InvDB are shown in two main views, the cDNA view and the Locus view, and six auxiliary databases with web-based viewers; DiseaseInfo Viewer, H-ANGEL, Clustering Viewer, G-integra, TOPO Viewer and Evola, and provided as flat files and XML files.

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