Abstract for presentation at 11th International Congress of Human Genetics

Lipid Molecular Evidence and Carotid Dynamic Index in Patients with Different ApoE Genotyping

  • Chin-San Liu, Vascular and Genomic Center, Changhua Christian Hospital, Changhua, Taiwan, Taiwan
  • Ching-Ling Kuo, Vascular and Genomic Center, Changhua Christian Hospital, Changhua, Taiwan, Taiwan
  • Wen-Ling Cheng, Vascular and Genomic Center, Changhua Christian Hospital, Changhua, Taiwan, Taiwan
  • Ching-Shan Huang, Vascular and Genomic Center, Changhua Christian Hospital, Changhua, Taiwan, Taiwan
  • Wan-Ju Tsai, Vascular and Genomic Center, Changhua Christian Hospital, Changhua, Taiwan, Taiwan

    • Background: APOE genotype was known as one of genetic risk of carotid atherosclerosis via lipid metabolism. However, poor evidence of lipid molecular or carotid dynamic index can support the relationship between carotid atherosclerosis and APOE genotyping.
    Methods: Subjects with clinical healthy subjects (N=300) were also enrolled without vascular events, diabetes and hypertension. Three APOE genotype groups were defined as APOE2 (including E2/E2, E3/E2 genotypes), APOE3 (E3/E3), and APOE4 (including E4/E3, E4/E4 genotypes). Carotid intima median thickness (IMT), total plaque index (TPI), mean of resistant index (mRI) and pulsate index (mPI) in carotid arteries were determined by carotid duplex system. Lipid moleculars including Cholesterol, LDL, oxidized LDL, lag-time of LDL oxidation, ApoB, ApoA and small Apoa were also surveyed.
    Results: Subjects harboring APOE4 allele revealed increased IMT, TPI, mRI, mPI druing study of carotid duplex. Moreover, higher level of cholersterol, LDL, oxidized LDL were also noted in persons harboring APOE4 allele. In contrast with APOE4 allele, subjects harboring APOE2 allele revealed the inverse response in their ultrasound index and lipid markers.
    Conclusion: ApoE4-related atherosclerosis may be involved in the process of dyslipidemia especially in quantitative, not qualitative, change in LDL molecular. Howevere, ApoE2 allele play a role of protect effect in carotid atherosclerosis.

    Conference Organiser - ICMS Pty Ltd